Regenerative Treatment · Non-surgical · In-office
P-Shot®
Priapus Shot®
A non-surgical regenerative injection using platelet-rich plasma (PRP) from your own blood to improve erectile function, sensitivity, tissue health, and overall sexual performance — without downtime or foreign substances.
Overview
What is the P-Shot®?
The Priapus Shot® is a regenerative injection that uses growth factors isolated from your own blood to stimulate tissue repair, improve blood flow, and enhance nerve function in penile tissue.
Unlike medications that work temporarily by increasing blood flow on demand, the P-Shot® aims to improve the underlying structure and function of the penis over time — making it a fundamentally different class of treatment.
It is commonly used for erectile dysfunction, reduced sensitivity, Peyronie’s disease, and sexual health decline associated with aging, diabetes, or post-prostate treatment recovery.
Platelet-Rich Plasma (PRP) is created by drawing a small blood sample and spinning it in a centrifuge to concentrate the platelets — cells packed with growth factors that signal tissue repair, new blood vessel formation, and cell regeneration. Because it comes from your own body, there is no risk of allergic reaction and no foreign substances are introduced. PRP has been used in orthopedics, wound care, and dermatology for decades.
Benefits
What the P-Shot® may improve
Results vary by individual. The following reflect outcomes commonly reported by patients and noted in clinical literature — not guarantees.
Stronger, firmer erections
Improved blood flow to penile tissue
Better response to ED medications
Reduced severity of erectile dysfunction
Increased sensitivity
Enhanced sexual pleasure
Improved orgasm quality
Restored sensation after nerve damage
May help reduce Peyronie’s curvature
Supports tissue regeneration and healing
Can contribute to increased fullness when combined with protocols
Non-surgical, in-office procedure
No foreign substances — uses your own blood
No downtime — resume normal activity same day
No risk of allergic reaction
What to expect
The procedure, step by step
Blood draw
A small sample of blood is drawn from your arm — similar in size to a standard lab test.
Centrifuge processing
The blood is spun to separate and concentrate the platelet-rich plasma from other components. This takes approximately 10 minutes.
Numbing
A topical numbing cream is applied and left for 20–30 minutes to ensure comfort during injection. Most patients report the numbing makes the procedure well-tolerated.
PRP injection
The concentrated PRP is injected into targeted areas of the penis using a fine needle. The injection itself takes only a few minutes.
Recovery
No downtime is required. Most men return to normal daily activity immediately. Results develop gradually over 2–6 weeks as tissue responds to the growth factors.
PRP therapy for erectile dysfunction has been evaluated in multiple clinical studies. Published research shows promising results for men with mild to moderate ED, particularly those with vascular or nerve-related causes. Large-scale randomized controlled trials are still ongoing. The P-Shot® protocol was developed by Dr. Charles Runels and uses PRP in a specific injection pattern designed for penile tissue. This page reflects current published evidence as of 2026.
PRP is FDA-cleared for processing, but the P-Shot® as a specific treatment protocol is not FDA-approved for erectile dysfunction. It is performed as an off-label use of PRP by licensed providers. This is common in regenerative medicine — many established treatments operate under off-label use.
How it compares
P-Shot® vs. related treatments
The P-Shot® is one of several PRP-based and regenerative options available. Here’s how it compares to closely related treatments on this site.
| Treatment | Type | Primary goal | Downtime |
|---|---|---|---|
| P-Shot® (this page) | PRP injection | Erectile function, sensitivity, tissue regeneration | None |
| P-Long Protocol™ | PRP + traction protocol | Gradual penile lengthening over time | None |
| P-Max™ | PRP-based combination | Enhanced function and size optimization | None |
| P-Thick™ | PRP-based filler | Immediate girth enhancement | Minimal |
| Shockwave Therapy | Energy-based | Vascular repair, ED improvement | None |
Is it right for you?
Who is a good candidate
The P-Shot® may be appropriate for men who:
Have mild to moderate erectile dysfunction and want a non-pharmaceutical option
Experience reduced sensitivity or changes in sensation with age
Have Peyronie’s disease and want to explore non-surgical treatment
Want to enhance the effects of existing ED medications
Are recovering from prostate treatment and want to support tissue healing
Have diabetes-related sexual health decline and want a regenerative approach
Are looking to optimize or combine with other enhancement protocols
Common questions
Frequently asked questions
Does the P-Shot® hurt?
Most patients report minimal discomfort. Topical numbing cream is applied beforehand and left on for 20–30 minutes, which makes the injection well-tolerated for the majority of men. Some report a mild pressure sensation during injection but not significant pain.
How long do results last?
Results typically last 12–18 months, though this varies based on individual health, lifestyle, and whether additional treatments are used. Maintenance sessions are generally recommended annually to sustain results.
How many treatments will I need?
Most providers recommend starting with one treatment and reassessing at 6–8 weeks. Some men see significant improvement after a single session; others benefit from a second treatment. Your provider will guide the plan based on your response.
Is the P-Shot® FDA approved?
PRP itself is FDA-cleared for processing. The P-Shot® as a specific treatment protocol is not FDA-approved for erectile dysfunction — it is performed as an off-label use of PRP. Off-label use is legal and common in medicine, particularly in regenerative therapies.
How is it different from Viagra or Cialis?
ED medications work temporarily by increasing blood flow on demand. The P-Shot® works differently — it aims to improve the underlying tissue quality and vascular health of the penis over time. Some men use both: the P-Shot® to address root causes, and medication as needed in the interim.
Can the P-Shot® increase size?
The P-Shot® alone is not primarily a size enhancement treatment. It can improve fullness and tissue quality. For more noticeable size improvement, it is often used in combination with protocols like P-Long™ or P-Max™. Discuss realistic expectations with your provider.
When will I see results?
Some changes may be noticeable within the first 2–3 weeks. Most men see continued improvement over 2–6 months as tissue responds to the growth factors. Results are gradual — this is not an immediate fix like a medication.
Also in regenerative treatments
Related treatments to explore
Ready to find a P-Shot® provider?
Browse our directory of vetted physicians offering the P-Shot® — or join the forum to hear from men who have been through the procedure.
This page is for informational purposes only and does not constitute medical advice, diagnosis, or treatment recommendations. Always consult a licensed physician before pursuing any medical procedure. Results vary by individual and are not guaranteed. PhallusMD does not endorse specific providers or guarantee clinical outcomes. The P-Shot® and Priapus Shot® are registered trademarks of Charles Runels, MD.